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The activation of PPAR- is a common denominator and a downstream target in the action of several obesogens [104, 124, 152, 207, 217], representing a putative approach for therapeutic intervention

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This synergy occurs because the two pathways converge on the same somatotroph cells, and their combined start produces a multiplicative rather than merely additive effect

doi: 10.1016/j.ejphar.2012.05.030, 50